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Clas-sically, the earliest hypotheses about depression cen-tered on the first three monoamines characterized in thebrain—norepinephrine, serotonin, and dopamine—alongwith the first transmitter discovered in the brain, in the1920s, acetylcholine. Matsumoto M et al (2004) Prognostic signi? cance of serine 392 phosphorylation in overex-pressed p53 protein in human esophageal squamous cell carcinoma.

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